Biosynthesis of cholesterol and fatty acids in tumor-bearing animals.

Much information has been published on the relationship of lipides to tumorigenesis (17), but most of the work has been concerned primarily with the more quantitative aspects of lipides in tumors and in the tissues of tumor-bearing ani mals. Investigations on the course of lipide bio genesis have been few. In a continuation of earlier work in this laboratory with normal animals (23), it seemed advisable to study the biosynthesis of cholesterol and fatty acids in tumor-bearing ani mals. In this report, as before, the incorporation of C14 from acetate-1-C14 into these substances is used to demonstrate their synthesis.